Funded Projects

Molecular glues are small molecules that promote or stabilize interactions between proteins, opening up targets previously considered undruggable and offering a less toxic alternative to conventional therapeutic approaches. In this collaboration, we evaluate Ambagon’s newly designed molecular glues through a series of in vitro assays and mechanistic studies. The project focuses on the evaluation of ternary complex kinetics using surface plasmon resonance (ResidenceTimer™), alongside cellular assays to assess the effect on colorectal cancer cell viability using proliferation assays. Furthermore, the functional impact of the molecular glues on disease-relevant pathways is explored using techniques such as qPCR and Western blotting.

The ACESO project aims to accelerate early-stage drug discovery by establishing an advanced, automated screening infrastructure in Oss. By combining state-of-the-art robotics, automation and assay technologies, ACESO enables researchers and industry partners to screen chemical libraries and identify potential starting points for the development of new medicines. The project aims to strengthen the Dutch drug discovery ecosystem and facilitate the translation of scientific discoveries into new therapeutic opportunities.