Pre-Profiled Anti Cancer Drugs

Anti Cancer Drugs List for Comparative Profiling, GeneNominator™ and SynergyFinder™

Compound

Synonym

Target

2-D08   SUMOylation
5-fluorouracil 5-FU, Adrucil, Carac, Efudex thymidylate synthase
6-thioguanine 6-TG purine antimetabolite
A-1210477*   BH3 mimetic for Mcl-1
A-420983   LCK
abemaciclib LY2835219, Verzenio, Verzenios CDK4/6
ABT-737   Bcl-2
acalabrutinib ACP-196, Calquence BTK
actinomycin-D dactinomycin, Cosmegen interfering with mRNA synthesis
adavosertib MK1775, AZD1775 Wee
afatinib BIBW 2992, Gilotrif, Giotrif, Afanix EGFR, ErbB2
alectinib CH5424802, Alecensa ALK
all-transretinoic-acid ATRA, Tretinoin, Vesanoid, Avita, Renova, Retin-a PML-RAR protein
alpelisib BYL719, Piqray PI3Kα
AMG-510   KRAS G12C
AMG-900   pan Aurora
anacardic acid*   SUMOylation
apitolisib GDC 0980 PI3Kα/ß/δ/γ
APR-246   p53 activator, PRIMA1-analog
ARQ-531   BTK
AT-7519   CDK1/2/4/6/9
AT-9283   JAK2/3
axitinib AG-013736, Inlyta, Axinix VEGFR1/2/3, PDGFRß, c-Kit
AZD-8055   mTOR
BAY293   KRAS-SOS1
BAY-320   Bub1
BAY11-7085   NFkB
BI-2536   Plk1
BIIB 021 CNF 2024 HSP90
BLU-9931   FGFR4
bortezomib PS-341, Velcade, Chemobort, Bortecad proteasome
bosutinib SKI-606, Bosulif Src, Abl
brigatinib AP26113, Alunbrig, Briganix ALK, EGFR
brivanib BMS-540215 VEGFR, FGFR, IGFR1
buparlisib BKM-120, NVP-BKM120 PI3K_p110α/ß/δ
busulfan Myleran, Busilvex, Busulfex IV chemotherapy
cabozantinib XL 184, BMS 907351, Cabometyx, Cometriq, Cabozanix VEGFR2, c-Met, Ret, Kit, Flt-1/3/4, Tie2, AXL
camptothecin CPT topoisomerase I
capecitabine* Xeloda thymidylate synthase
carboplatin Paraplatin DNA
carfilzomib PR-171-007, Kyprolis proteasome
CB-1158* INCB001158 arginase
ceritinib LDK 378, Zykadia ALK
CHIR-124   Chk1
cisplatin CDDP, Platinol DNA
cobimetinib GDC-0973, XL-518, Cotellic MEK1
copanlisib BAY 80-6946, Aliqopa PI3K, AKT, mTOR
crenolanib   FLT3, PDGFRα/ß
crizotinib PF-02341066, Xalkori, Crizonix c-Met, ALK
CYC116   Aurora, VEGFR2
cytarabine ara-C, Cytosar-U, Depocyt DNA synthesis inhibitor
dabrafenib GSK2118436, Tafinlar B-RAF
dacarbazine imidazole carboxamide, DTIC-Dome chemotherapy
dacomitinib PF-299804, PF299, Vizimpro EGFR
dactolisib BEZ235, NVP-BEZ235 PI3K, mTOR, ATR
danusertib PHA-739358 pan Aurora
dasatinib BMS-354825, Sprycel, Dasanix Abl, Src, c-Kit
daunorubicin daunomycin, Cerubidine DNA, RNA synthesis
degrasyn WP1130 USP9x/5/14, UCH37, other activity (Bcr/Abl)
derazantinib ARQ 087, BAL087 FGFR2
dinaciclib SCH727965 CDK1/2/5/9
docetaxel RP56976, DTX, DXL, Taxotere, Docecad microtubule
doxifluridine 5-dFdU nucleoside analog prodrug
doxorubicin Adriamycin, Caelyx, Myocet topoisomerase II
duvelisib IPI-145, Copiktra PI3Kδ/γ
entinostat MS-275, SNDX-275 HDAC1/3
entrectinib RXDX-101, NMS-E628, Rozlytrek TrkA, TrkB, RrkC, ROS1, ALK
epirubicin Ellence, Pharmorubicin, Epirubicin Ebewe topoisomerase II
epothilone B EPO906, patupilone microtubule
EPZ-005687*   EZH2, ARID1A
erdafitinib JNJ-42756493, Balversa FGFR
eribulin E7389, ER 086526, Halaven tubulin
erismodegib* NVP-LDE-225 Smo, Hedgehog
erlotinib Tarceva EGFR
etoposide VP16, Etopophos, Toposar topoisomerase II
everolimus RAD001, Zortress, Certican, Afinitor, Votubia, Evertor mTOR inhibitor of FKBP12
fasudil* HA-1077 ROCK-II, PKA, PKG, PKC, MLCK
fenebrutinib GDC-0853, FEN BTK
fosfamatinib Tavalisse, Tavlesse prodrug of tamatinib, Syk
fulvestrant Faslodex oestrogen receptor antagonist
GDC-0152   XIAP, IAP
gefitinib ZD1839, Iressa EGFR
gemcitabine Gemzar DNA synthesis inhibitor
gilteritinib   FLT3, AXL
GSK-1070916   Aurora B/C
GSK-126   EZH2, ARID1A
GSK-1838705A   IGF-1R, IR, ALK
GSK-343   EZH2, ARID1A
GSK-461364   Plk1
ibrutinib PCI-32765, Imbruvica, Ibrutix BTK
ICG-001   antagonizes Wnt/ß-catenin, TCF-mediated transcription and specifically binds to element-binding protein (CBP)
idelalisib CAL-101, GS-1101, Zydelig PI3Kγ
imatinib STI-571, Gleevec, Glivec v-Abl, c-Kit, PDGFR 
infigratinib BGJ-398, NVP-BGJ-398 FGFR1/2/3 
ipatasertib GDC-0068, RG7440 Akt
irbinitinib tucatinib, ARRY-380, ONT-380 ErbB2
irinotecan Camptosar, Campto, Onivyde topoisomerase I
JQ1   BET bromodomain inhibitor, BRD4
KU-60019   ATM
lapatinib GSK-572016, Tykerb, Tyverb EGFR, ErbB2
larotrectinib LOXO-101, ARRY-470, Vitrakvi TrkA, TrkB, TrkC
LB42708   farnesyltransferase
lenvatinib E7080, Lenvima, Lenvanix VEGFR
LGK-974   porcupine (Wnt signaling antagonist)
lorlatinib PF-6463922, Lorbrena, Lorviqua ALK, ROS1
macitentan* Opsumit ETA, ETB receptor
masitinib AB1010, Masivet, Kinavet Kit, PDGFRα/ß
melphalan Alkeran, Evomela, Sarcolysin alkylating agent
mercaptopurine 6-MP, 6-mercaptopurine, Purinethol purine synthase
methotrexate amethopterin, Trexall, Rheumatrex dihydrofolate reductase (DHFR)
MG132   proteasome
midostaurin PKC412, Rydapt FLT3
mitomycin-C   DNA crosslinker
mitoxantrone mitozantrone, Novantrone topoisomerase II
MK-2206   Akt1/2/3
MK-5108 VX-689 Aurora A
ML-792   SUMOylation
MLN-7243 TAK-243 ubiquitin-activating enzymes, E1
MLN-8054   Aurora A
momelotinib GS-0387, CYT-387 JAK1/2, TBK1
molibresib I-BET-762, GSK-525762 BET proteins
MPI-0479605   TTK (MPS1)
MPS1-IN-1   TTK (MPS1)
MRK-560   gamma secretase
mubritinib TAK165 ErbB2
navitoclax ABT-263 Bcl-xL, Bcl-2, Bcl-w
neratinib HKI-272, Nerlynx, Hernix EGFR, ErbB2
nilotinib AMN-107, Tasigna Bcr-Abl
nintedanib BIBF 1120, Vargatef, Ofev triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3, PDGFRa/ß
niraparib MK-4827, Zejula PARP
NMS-P715   TTK (MPS1)
nutlin 3a   P53wt
NVP-ADW742   IGF-1R
obatoclax GX15-070 Bcl-2
olaparib AZD-2281, MK-7339, Ku-0059436, Lynparza PARP1/2
osimertinib merelitinib, Tagrisso, Tagrix EGFR
paclitaxel Taxol microtubule
palbociclib PD 0332991, Ibrance CDK4/6
panobinostat LBH 589, Farydak HDAC
pazopanib GW786034, Votrient VEGFR1/2/3, PDGFR, FGFR, c-Kit, c-Fms
PD-0325901   MEK
pelitinib EKB-569 EGFR
pemigatinib Pemazyre FGFR2
pevonedistat MLN4924 NEDD8
pexidartinib PLX3397, Turalio FMS (CSF-1R), KIT
PHA-793887   CDK2/5/7
pictilisib GDC-0941 PI3Kα/δ
pilaralisib* XL-147 PI3Kα/δ/γ
pinometostat* EPZ-5676 methyltransferase DOT1L
ponatinib AP24534, Iclusig Abl, PDGFRa, VEGFR2, FGFR1, Src
prednisolone   GR
quizartinib AC220 FLT3
regorafenib BAY 73-4506, Stivarga, Regonix VEGFR1/2/3, PDGFRß, Kit, RET and Raf-1
reversine   A3 adenosine receptor antagonist, pan Aurora, TTK
ribociclib LEE-011, Kisqali CDK4/6
rucaparib PF-01367338, AG014699, Rubraca PARP
ruxolitinib INCB018424, INC424, Jakafi, Jakavi JAK1/2
SCH-900776 MK-8776 Chk1
seliciclib* CYC202, roscovitine CDK
selumetinib AZD6244, ARRY-142886 MEK1
SGX-523*   Met
SN-38   topoisomerase I, active metabolite of CPT-11
sonidegib* NVP-LDE-225, erismodegib Smo, Hedgehog
sorafenib sorafenib tosylate, Nexavar Raf-1, B-Raf, VEGFR-2
STLC S-trityl-L-cysteine kinesin Eg5
streptozocin* streptozotocin, Zanosar ribosome
sunitinib SU11248, Sutent VEGFR2 (Flk-1), PDGFRß, c-Kit
talazoparib BMN-673, Talzenna PARP
tamatinib R-406 Syk
taselisib GDC-0032 PI3K mutant
tazemetostat EPZ-6438, Tazverik EZH2, ARID1A
temozolomide* Temodar, Temodal, Temcad DNA damage inducer
temsirolimus CCI-779, NSC 683864, Torisel mTOR
TGX-221   PI3K
TH-588   microtubule (formerly reported as MTH1 (NUDT1) inhibitor)
tivozanib AV-951, Fotivda VEGFR
tofacitinib CP-690550, Xeljanz, Jakvinus, Tofacinix JAK3
tomivosertib eFT508 MNK1/2
topotecan Hycamtin topoisomerase I
tozasertib VX-680 pan-Aurora
trametinib Mekinist, GSK1120212 MEK1/2
trastuzumab Herceptin, Herzuma HER2
trastuzumab emtansine ado-trastuzumab emtansine, Kadcyla HER2
ulixertinib BVD-523, VRT752271 ERK1/2
UMI-77   Mcl-1, Bcl-2
UNC-1999   EZH2, ARID1A
vandetanib ZD6474, Caprelsa VEGFR2
vatalanib* PTK787, PTK/ZK VEGFR2, KDR
vecabrutinib SNS-062 BTK, ITK
vemurafenib PLX4032, RG7204, RO5185426, Zelboraf B-RAF
venetoclax* GDC-0199, ABT-199, RG7601, Venclexta, Venclyxto Bcl-2
vinblastine vincaleukoblastine, Velban mitosis
vincristine leurocristine, Oncovin, Vincasar tubulin
vinflunine Javlor tubulin
volasertib BI 6727 PLK1
vorinostat suberanilohydroxamic acid, SAHA, MK0683, Zolinza HDAC
XAV-939   tankyrase1/2
zanubrutinib BGB-3111, Brukinsa BTK

Compounds with an asterisk (*) are excluded from the comparative analysis.

go to OncolinesProfiler™
go to GeneNominator™
go to SynergyFinder™