Pre-Profiled Anti Cancer Drugs

Anti Cancer Drugs List for Comparative Profiling, GeneNominator™ and SynergyFinder™

Compound

Synonym

Target

2-D08 SUMOylation
5-fluorouracil 5-FU, Adrucil, Carac, Efudex thymidylate synthase
6-thioguanine 6-TG purine antimetabolite
A-1210477* BH3 mimetic for Mcl-1
abemaciclib LY2835219, Verzenio, Verzenios CDK4/6
ABT-737 Bcl-2
acalabrutinib ACP-196, Calquence BTK
actinomycin-D dactinomycin, Cosmegen interfering with mRNA synthesis
adavosertib MK1775, AZD1775 Wee
afatinib BIBW 2992, Gilotrif, Giotrif, Afanix EGFR, ErbB2
alectinib CH5424802, Alecensa ALK
all-transretinoic-acid ATRA, Tretinoin, Vesanoid, Avita, Renova, Retin-a PML-RAR protein
alpelisib BYL719, Piqray PI3Kα
AMG-900 pan Aurora
anacardic acid* SUMOylation
apitolisib GDC 0980 PI3Kα/ß/δ/γ
AT-7519 CDK1/2/4/6/9
AT-9283 JAK2/3
axitinib AG-013736, Inlyta, Axinix VEGFR1/2/3, PDGFRß, c-Kit
AZD-8055 mTOR
BAY11-7085 NFkB
BI-2536 Plk1
BIIB 021 CNF 2024 HSP90
BLU-9931 FGFR4
bortezomib PS-341, Velcade, Chemobort, Bortecad proteasome
bosutinib SKI-606, Bosulif Src, Abl
brigatinib AP26113, Alunbrig, Briganix ALK, EGFR
brivanib BMS-540215 VEGFR, FGFR, IGFR1
buparlisib BKM-120, NVP-BKM120 PI3K_p110α/ß/δ
busulfan Myleran, Busilvex, Busulfex IV chemotherapy
cabozantinib XL 184, BMS 907351, Cabometyx, Cometriq, Cabozanix VEGFR2, c-Met, Ret, Kit, Flt-1/3/4, Tie2, AXL
camptothecin CPT topoisomerase I
capecitabine* Xeloda thymidylate synthase
carboplatin Paraplatin DNA
carfilzomib PR-171-007, Kyprolis proteasome
ceritinib LDK 378, Zykadia ALK
CHIR-124 Chk1
cisplatin CDDP, Platinol DNA
cobimetinib GDC-0973, XL-518, Cotellic MEK1
copanlisib BAY 80-6946, Aliqopa PI3K, AKT, mTOR
crizotinib PF-02341066, Xalkori, Crizonix c-Met, ALK
cytarabine ara-C, Cytosar-U, Depocyt DNA synthesis inhibitor
dabrafenib GSK2118436, Tafinlar B-RAF
dacarbazine imidazole carboxamide, DTIC-Dome chemotherapy
dacomitinib PF-299804, PF299, Vizimpro EGFR
dactolisib BEZ235, NVP-BEZ235 PI3K, mTOR, ATR
danusertib PHA-739358 pan Aurora
dasatinib BMS-354825, Sprycel, Dasanix Abl, Src, c-Kit
daunorubicin daunomycin, Cerubidine DNA, RNA synthesis
degrasyn WP1130 USP9x/5/14, UCH37, other activity (Bcr/Abl)
dinaciclib SCH727965 CDK1/2/5/9
docetaxel RP56976, DTX, DXL, Taxotere, Docecad microtubule
doxorubicin Adriamycin, Caelyx, Myocet topoisomerase II
duvelisib IPI-145, Copiktra PI3Kδ/γ
entinostat MS-275, SNDX-275 HDAC1/3
epirubicin Ellence, Pharmorubicin, Epirubicin Ebewe topoisomerase II
epothilone B EPO906, patupilone microtubule
EPZ-005687 EZH2, ARID1A
erlotinib Tarceva EGFR
etoposide VP16, Etopophos, Toposar topoisomerase II
everolimus RAD001, Zortress, Certican, Afinitor, Votubia, Evertor mTOR inhibitor of FKBP12
fasudil* HA-1077 ROCK-II, PKA, PKG, PKC, MLCK
fulvestrant Faslodex oestrogen receptor antagonist
GDC-0152 XIAP, IAP
gefitinib ZD1839, Iressa EGFR
gemcitabine Gemzar DNA synthesis inhibitor
GSK-1070916 Aurora B/C
GSK-126 EZH2, ARID1A
GSK-1838705A IGF-1R, IR, ALK
GSK-343 EZH2, ARID1A
GSK-461364 Plk1
ibrutinib PCI-32765, Imbruvica, Ibrutix BTK
ICG-001 antagonizes Wnt/ß-catenin, TCF-mediated transcription and specifically binds to element-binding protein (CBP)
idelalisib CAL-101, GS-1101, Zydelig PI3Kγ
imatinib STI-571, Gleevec, Glivec v-Abl, c-Kit, PDGFR 
infigratinib BGJ-398, NVP-BGJ-398 FGFR1/2/3 
ipatasertib GDC-0068, RG7440 Akt
irbinitinib tucatinib, ARRY-380, ONT-380 ErbB2
irinotecan Camptosar, Campto, Onivyde topoisomerase I
JQ1 BET bromodomain inhibitor, BRD4
KU-60019 ATM
lapatinib GSK-572016, Tykerb, Tyverb EGFR, ErbB2
LB42708 farnesyltransferase
lenvatinib E7080, Lenvima, Lenvanix VEGFR
LGK-974 porcupine (Wnt signaling antagonist)
macitentan* Opsumit ETA, ETB receptor
masitinib AB1010, Masivet, Kinavet Kit, PDGFRα/ß
melphalan Alkeran, Evomela, Sarcolysin alkylating agent
mercaptopurine 6-MP, 6-mercaptopurine, Purinethol purine synthase
methotrexate amethopterin, Trexall, Rheumatrex dihydrofolate reductase (DHFR)
MG132 proteasome
midostaurin PKC412, Rydapt FLT3
mitomycin-C DNA crosslinker
mitoxantrone mitozantrone, Novantrone topoisomerase II
MK-2206 Akt1/2/3
MK-5108 VX-689 Aurora A
MLN-7243 TAK-243 ubiquitin-activating enzymes, E1
MLN-8054 Aurora A
momelotinib GS-0387, CYT-387 JAK1/2, TBK1
molibresib I-BET-762, GSK-525762 BET proteins
MPI-0479605 TTK (MPS1)
MPS1-IN-1 TTK (MPS1)
mubritinib TAK165 ErbB2
navitoclax ABT-263 Bcl-xL, Bcl-2, Bcl-w
neratinib HKI-272, Nerlynx, Hernix EGFR, ErbB2
nilotinib AMN-107, Tasigna Bcr-Abl
nintedanib BIBF 1120, Vargatef, Ofev triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3, PDGFRa/ß
niraparib MK-4827, Zejula PARP
NMS-P715 TTK (MPS1)
nutlin 3a P53wt
NVP-ADW742 IGF-1R
obatoclax GX15-070 Bcl-2
olaparib AZD-2281, MK-7339, Ku-0059436, Lynparza PARP1/2
osimertinib merelitinib, Tagrisso, Tagrix EGFR
paclitaxel Taxol microtubule
palbociclib PD 0332991, Ibrance CDK4/6
panobinostat LBH 589, Farydak HDAC
pazopanib GW786034, Votrient VEGFR1/2/3, PDGFR, FGFR, c-Kit, c-Fms
PD-0325901 MEK
pegaspargase Oncaspar asparagine
pevonedistat MLN4924 NEDD8
pexidartinib PLX3397, Turalio FMS (CSF-1R), KIT
PHA-793887 CDK2/5/7
pictilisib GDC-0941 PI3Kα/δ
pilaralisib* XL-147 PI3Kα/δ/γ
pinometostat* EPZ-5676 methyltransferase DOT1L
ponatinib AP24534, Iclusig Abl, PDGFRa, VEGFR2, FGFR1, Src
prednisolone GR
quizartinib AC220 FLT3
regorafenib BAY 73-4506, Stivarga, Regonix VEGFR1/2/3, PDGFRß, Kit, RET and Raf-1
reversine A3 adenosine receptor antagonist, pan Aurora, TTK
ribociclib LEE-011, Kisqali CDK4/6
rucaparib PF-01367338, AG014699, Rubraca PARP
ruxolitinib INCB018424, INC424, Jakafi, Jakavi JAK1/2
SCH-900776 MK-8776 Chk1
seliciclib CYC202, roscovitine CDK
selumetinib AZD6244, ARRY-142886 MEK1
SGX-523* Met
SN-38 topoisomerase I, active metabolite of CPT-11
sonidegib* NVP-LDE-225, erismodegib Smo, Hedgehog
sorafenib sorafenib tosylate, Nexavar Raf-1, B-Raf, VEGFR-2
STLC S-trityl-L-cysteine kinesin Eg5
streptozocin* streptozotocin, Zanosar ribosome
sunitinib SU11248, Sutent VEGFR2 (Flk-1), PDGFRß, c-Kit
talazoparib BMN-673, Talzenna PARP
taselisib GDC-0032 PI3K mutant
tazemetostat EPZ-6438, Tazverik EZH2, ARID1A
temozolomide Temodar, Temodal, Temcad DNA damage inducer
temsirolimus CCI-779, NSC 683864, Torisel mTOR
TGX-221 PI3K
TH-588 MTH1 (NUDT1) inhibitor
tivozanib AV-951, Fotivda VEGFR
tofacitinib CP-690550, Xeljanz, Jakvinus, Tofacinix JAK3
tomivosertib eFT508 MNK1/2
topotecan Hycamtin topoisomerase I
tozasertib VX-680 pan-Aurora
trametinib Mekinist, GSK1120212 MEK1/2
ulixertinib BVD-523, VRT752271 ERK1/2
UMI-77 Mcl-1, Bcl-2
UNC-1999 EZH2, ARID1A
vandetanib ZD6474, Caprelsa VEGFR2
vatalanib PTK787, PTK/ZK VEGFR2, KDR
vemurafenib PLX4032, RG7204, RO5185426, Zelboraf B-RAF
venetoclax GDC-0199, ABT-199, RG7601, Venclexta, Venclyxto Bcl-2
vinblastine vincaleukoblastine, Velban mitosis
vincristine leurocristine, Oncovin, Vincasar tubulin
volasertib BI 6727 PLK1
vorinostat suberanilohydroxamic acid, SAHA, MK0683, Zolinza HDAC
XAV-939 tankyrase1/2

Compounds with an asterisk (*) are excluded from the comparative analysis due to inactivity in all Oncolines™ cancer cell lines.

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